منابع مشابه
BAF goes nuclear
Two channels, one program he biophysical and structural characteristics of chloride ion channels have been studied extensively, but little is known about the molecular regulation and signaling pathways associated with these highly conserved proteins. Rutledge et al. (page 435) analyzed the activation of the CLH-3 chloride ion channel in C. elegans during meioitic cell cycle progression and in r...
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microRNAs (miRNAs), defined as 21-24 nucleotide non-coding RNAs, are important regulators of gene expression. Initially, the functions of miRNAs were recognized as post-transcriptional regulators on mRNAs that result in mRNA degradation and/or translational repression. It is becoming evident that miRNAs are not only restricted to function in the cytoplasm, they can also regulate gene expression...
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Arrestins are a family of scaffolding proteins that are closely associated with the function of seven transmembrane domain G protein-coupled receptors (GPCRs). In mammals, two members of the arrestin family, the visual arrestins, are restricted to photoreceptor cells, whereas two others, β-arrestin 1 and β-arrestin 2, are expressed ubiquitously. These proteins promote the internalization and de...
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fine reticulum that pokes its fingers across the nucleus is capable of storing and releasing calcium, according to Wihelma Echevarría, Michael Nathanson (Yale University, New Haven, CT), and colleagues. The physiological activators of the compartment remain obscure, but they could potentially induce localized signaling in the nucleus. Intranuclear extensions of the ER have been described previo...
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136 biotech and life sciences worldwide as part of a larger project to map human technological development (Fig 1). “Maps can help answer or at least address a number of key questions,” said Hoffman. “Where around the world is biotech really happening or beginning to happen? How important is economic geography now that the life sciences are spilling out of university, governmental and industria...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2002
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1583iti4